This review highlights the recent applications of Ir-catalyzed reactions in the total synthesis of natural products. On the basis of the type of Ir-catalyzed reaction, the applications will be grouped into four main sections, including transfer hydrogenation reactions, hydrogenation reactions, allylic substitution reactions and C–H borylation reactions. The examples presented demonstrate the high efficiency of the entitled reactions in the formation of chemical bonds and the construction of naturally occurring skeletons.