Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes†,10.1039/C1CC12805A

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Kinetic discrimination in recognition of DNA quadruplex targets by guanine-rich heteroquadruplex-forming PNA probes†

Subhadeep Roy,Kimberly J. Zanotti,Connor T. Murphy,Farial A. Tanious,W. David Wilson,Danith H. Ly,Bruce A. Armitage

Chemical Communications Pub Date : 06/30/2011 00:00:00 , DOI:10.1039/C1CC12805A

Abstract

Guanine-rich peptide nucleic acid probes hybridize to DNA G quadruplex targets with high affinity, forming PNA–DNA heteroquadruplexes. We report a surprising degree of kinetic discrimination for PNA heteroquadruplex formation with a series of DNA targets. The fastest hybridization is observed for targets folded into parallel morphologies.