Low-dose HSP90 inhibitors DPB and AUY-922 repress apoptosis in HUVECs†,10.1039/C5RA10989B

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Low-dose HSP90 inhibitors DPB and AUY-922 repress apoptosis in HUVECs†

Li-Qi Yao,Le Su,Shang-Li Zhang,Bao-Xiang Zhao,Jun-Ying Miao

RSC Advances Pub Date : 09/03/2015 00:00:00 , DOI:10.1039/C5RA10989B

Abstract

In this study, we found that low-dose HSP90 inhibitors DPB and AUY-922 could unexpectedly restrain apoptosis in HUVECs. This hormesis was accompanied by the increase of p-AKT1. Our findings could have significant implications for the administration of HSP90 inhibitors in vascular diseases and cancer.