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An efficient and novel approach for the synthesis of substituted N-aryl lactams
Devdutt Chaturvedi,Amit K. Chaturvedi,Nisha Mishra,Virendra Mishra
Organic & Biomolecular Chemistry Pub Date : 10/16/2012 00:00:00 , DOI:10.1039/C2OB26230D
Abstract

A quick, efficient, one-pot method for the synthesis of substituted N-aryl lactams through the reaction of various kinds of corresponding substituted arenes with a variety of ω-azido alkanoic acid chlorides using a Lewis acid (i.e. EtAlCl2) at room temperature, through the in situ involvement of a Friedel–Crafts reaction followed by intramolecular Schimdt rearrangement was developed, and afforded good to excellent yields.

Graphical abstract: An efficient and novel approach for the synthesis of substituted N-aryl lactams
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