Metal-free tandem reaction synthesis of spiro-cyclopropyl fused pyrazolin-5-one derivatives†
Man Liu,Chen-Fei Liu,Jing Zhang,Yan-Jun Xu,Lin Dong
Organic Chemistry Frontiers Pub Date : 01/21/2019 00:00:00 , DOI:10.1039/C8QO01378K
Abstract

A highly efficient cascade annulation approach was developed for the synthesis of novel spiro-cyclopropyl fused pyrazolin-5-ones from pyrazole-3-ketone substrates and two-component sulfur ylides in an acidic environment. This metal-free one-pot reaction has the advantages of easily available active materials, simple operation and brand new spirocyclic skeletons.

Graphical abstract: Metal-free tandem reaction synthesis of spiro-cyclopropyl fused pyrazolin-5-one derivatives