A simple and an efficient method has been developed for the one-pot multicomponent synthesis of pyrano[2,3-d]-pyrimidine derivatives. This was achieved through the condensation reaction between dimethylbarbituric acid, aromatic aldehyde and malononitrile in the presence of a Mn/ZrO₂ heterogeneous catalyst with ethanol/water mixture as solvent for only 1 hour. Further advantages of this synthesis methodology include excellent yields, mild reaction conditions, atom economy, environmentally friendliness, reusable catalyst and no need for chromatographic separations.