Activation of enzyme nanogel in organic solvents by PEG–substrate joint imprinting†,10.1039/C4RA06660J

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Activation of enzyme nanogel in organic solvents by PEG–substrate joint imprinting†

Rui Wang,Yifei Zhang,Jun Ge,Zheng Liu

RSC Advances Pub Date : 08/14/2014 00:00:00 , DOI:10.1039/C4RA06660J

Abstract

A substrate or polyethyleneglycol (PEG) imprinted lipase nanogel displayed increased apparent activity in organic solvents by 2.5–4.7 folds, compared to native lipase. It enabled a one-step synthesis of chloramphenicol palmitate with a yield of ∼99% and purity of ∼99%, indicating that the imprinted lipase nanogel is an appealing catalyst in organic media.