An ESR and DFT study of hydration of the 2′-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate†,10.1039/C4CC07089E

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

An ESR and DFT study of hydration of the 2′-deoxyuridine-5-yl radical: a possible hydroxyl radical intermediate†

Lidia Chomicz,Alex Petrovici,Ian Archbold,Amitava Adhikary,Anil Kumar,Michael D. Sevilla,Janusz Rak

Chemical Communications Pub Date : 10/01/2014 00:00:00 , DOI:10.1039/C4CC07089E

Abstract

The mechanism of radiation-induced frank strand break formation in irradiated 5-bromo-2′-deoxyuridine (BrdU)-labelled DNA is still unclear despite the proven radiosensitizing properties of BrdU. Combination of ESR spectroscopy and quantum chemical modelling points to a simple reaction between the uridine-5-yl radical and water molecules that produces the genotoxic hydroxyl radical.