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Palladium-catalysed ligand-free reductive Heck cycloisomerisation of 1,6-en-α-chloro-enamides†
Yangyang Hou,Jing Ma,Hongyi Yang,Edward A. Anderson,Andy Whiting
Chemical Communications Pub Date : 03/04/2019 00:00:00 , DOI:10.1039/C9CC00537D
Abstract

The first example of an intramolecular hydroarylation of 1,6-en-α-chloro-enamides was achieved by a palladium-catalysed ligand-free reductive Heck cycloisomerisation with no competing Heck-cyclised by-product.

Graphical abstract: Palladium-catalysed ligand-free reductive Heck cycloisomerisation of 1,6-en-α-chloro-enamides
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