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Palladium-catalyzed copper(i)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling†
Vaibhav Pravinchandra Mehta,Virinder Singh Parmar,Erik Van der Eycken
Organic & Biomolecular Chemistry Pub Date : 08/06/2007 00:00:00 , DOI:10.1039/B704389A
Abstract

The application of a palladium-catalyzed Cu(I)-mediated Liebeskind–Srogl protocol for the decoration of the 2(1H)-pyrazinone scaffold resulted in significantly improved yields and rates when performed under microwave irradiation with simultaneous cooling.

Graphical abstract: Palladium-catalyzed copper(i)-mediated cross-coupling of arylboronic acids and 2(1H)-pyrazinones facilitated by microwave irradiation with simultaneous cooling
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