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Palladium-catalyzed paraformaldehyde insertion: a three-component synthesis of benzofurans†
Xiufang Cheng,Yi Peng,Jun Wu,Guo-Jun Deng
Organic & Biomolecular Chemistry Pub Date : 02/04/2016 00:00:00 , DOI:10.1039/C6OB00198J
Abstract

An efficient procedure for 2-aroylbenzofuran preparation from 2-bromophenols, phenacyl bromides and paraformaldehyde is described. The cheap and stable paraformaldehyde served as the carbon source via an in situ formylation reaction.

Graphical abstract: Palladium-catalyzed paraformaldehyde insertion: a three-component synthesis of benzofurans
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