Photo-cross-linking using trifluorothymidine and 3-cyanovinylcarbazole induced a large shifted 19F MR signal†,10.1039/C5CC02972D

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Photo-cross-linking using trifluorothymidine and 3-cyanovinylcarbazole induced a large shifted 19F MR signal†

Shigetaka Nakamura

Chemical Communications Pub Date : 04/29/2015 00:00:00 , DOI:10.1039/C5CC02972D

Abstract

Photo-cross-linking of trifluorothymidine (^TFT) using 3-cyanovinylcarbazole (^CNVK) clearly shifted its ¹⁹F nuclear magnetic resonance (NMR) signal 8 ppm. This ^CNVK mediated ultrafast photo-cross-linking-induced shift can be utilized for miRNA detection by hybridization chain reaction (HCR) to detect 10 nM of a target in a sequence-specific manner.