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Racemic and diastereoselective construction of indole alkaloids under solvent- and catalyst-free microwave-assisted Pictet–Spengler condensation†
Mouhamad Jida,Olivier-Mohamad Soueidan,Benoit Deprez,Guillaume Laconde,Rebecca Deprez-Poulain
Green Chemistry Pub Date : 02/22/2012 00:00:00 , DOI:10.1039/C2GC16596A
Abstract

An environment-friendly high-yielding method for the racemic and asymmetric diastereoselective preparation of indole alkaloids via Pictet–Spengler reaction is reported. The reaction proceeds with short reaction times under solvent-free and microwave-irradiation conditions.

Graphical abstract: Racemic and diastereoselective construction of indole alkaloids under solvent- and catalyst-free microwave-assisted Pictet–Spengler condensation
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