Zinc–bromine batteries (ZBBs) receive wide attention in distributed energy storage because of the advantages of high theoretical energy density and low cost. However, their large-scale application is still confronted with some obstacles. Therefore, in-depth research and advancement on the structure, electrolyte, anode, cathode and membrane are of great significance and impendency. Herein, we review the past and present investigations on ZBBs, discuss the key problems and technical challenges, and propose perspectives for the future, with the focus on materials and chemistry. This perspective would provide valuable information on further development of ZBBs.