Regioselective synthesis of densely functionalized, enantiopure, sugar–pyrazole hybrids as potential scaffolds for drug discovery†‡
Mohammad Saquib,Irfan Husain,Ruchir Kant,Sanjeev Meena,H. M. Gauniyal,Sudhir Sinha,P. R. Maulik,Arun K. Shaw
Abstract
A versatile new synthetic strategy utilizing MBH chemistry for the assembly of highly functionalized enantiopure sugar–pyrazole hybrid molecules with multiple sites for structural diversification and a non-flat skeleton as potential drug scaffolds is reported. Four representative hybrid molecules were screened for in vitro anti-cancer activity, wherein three of them were found to exhibit good anti-cancer activity.
