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Resorufin based fluorescence ‘turn-on’ chemodosimeter probe for nitroxyl (HNO)†
Kondapa Naidu Bobba,Ying Zhou,Lin E. Guo,Tie Nan Zang,Jun Feng Zhang
RSC Advances Pub Date : 10/01/2015 00:00:00 , DOI:10.1039/C5RA17837A
Abstract

A cellular responsive, highly selective fluorogenic and chromogenic chemodosimeter probe for HNO is developed. This new probe showed ∼30 fold fluorescence enhancement in the presence of HNO and is sensitive to HNO at concentrations as low as 0.02 μM. Further, it is capable of detecting HNO levels in cellular milieus as well as in live specimens e.g. C. elegans.

Graphical abstract: Resorufin based fluorescence ‘turn-on’ chemodosimeter probe for nitroxyl (HNO)
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