Ruthenium- and osmium-arene-based paullones bearing a TEMPO free-radical unit as potential anticancer drugs†
Vladimir B. Arion,Anatolie Dobrov,Simone Göschl,Michael A. Jakupec,Bernhard K. Keppler,Peter Rapta
Chemical Communications Pub Date : 07/02/2012 00:00:00 , DOI:10.1039/C2CC33786J
Abstract
A modified paullone ligand bearing a TEMPO free-radical unit (HL) and its ruthenium(II) and osmium(II)-arene complexes [M(p-cymene)(HL)Cl]Cl·nH2O (M = Ru, Os) exhibit high antiproliferative activity in human cancer cell lines.
