960化工网
Straightforward synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization†
Wuji Sun,Xue Ma,Yuqi Pang,Lifeng Zhao,Qidi Zhong,Chunyan Liu,Qiangwen Fan
RSC Advances Pub Date : 01/07/2022 00:00:00 , DOI:10.1039/D1RA07944A
Abstract

A green, simple and efficient method is developed for the synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization of 2-aminobenzamides and aldehydes under visible light irradiation. The reaction proceeds using fluorescein as a photocatalyst in the presence of TBHP without the need for a metal catalyst. In addition, this reaction tolerates a broad scope of substrates and could afford a variety of desirable products in good to excellent yields. Thus, the present synthetic method provides a straightforward strategy for the synthesis of quinazolin-4(3H)-ones.

Graphical abstract: Straightforward synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization
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