Substrate control of stereoselection in the rhodium(i) catalyzed intramolecular [4 + 2] cycloaddition reaction†
Donogh J. R. O'Mahony,David B. Belanger,Tom Livinghouse
Organic & Biomolecular Chemistry Pub Date : 05/19/2003 00:00:00 , DOI:10.1039/B302426C
Abstract

The Rh(I) catalyzed intramolecular [4 + 2] cycloaddition of representative achiral and chiral enedienes has been shown to proceed with excellent levels of stereoselectivity and in high yield under mild reaction conditions. In contrast, the corresponding noncatalyzed cycloadditions for three substrates in the latter category require higher temperatures and exhibit low levels of stereocontrol.

Graphical abstract: Substrate control of stereoselection in the rhodium(i) catalyzed intramolecular [4 + 2] cycloaddition reaction