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Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions†
Trimurti L. Lambat,Ahmed A. Abdala,Sami Mahmood,Pankaj V. Ledade,Ratiram G. Chaudhary,Subhash Banerjee
RSC Advances Pub Date : 12/03/2019 00:00:00 , DOI:10.1039/C9RA08478A
Abstract

We report an efficient and facile one-pot synthesis of 4-oxo-tetrahydroindoles using sulfamic acid under ball milling conditions. The present protocol for preparation of biologically important 4-oxo-tetrahydroindoles offers several advantages such as mild reaction conditions, improved selectivity and higher isolated yields. Moreover, solvent-free reaction conditions and the use of ball milling make the present protocol environmentally friendly in nature.

Graphical abstract: Sulfamic acid promoted one-pot multicomponent reaction: a facile synthesis of 4-oxo-tetrahydroindoles under ball milling conditions
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