Synthesis and structure of [Zn(OMe)(L)]·[Zn(OH)(L)]·2(BPh4), L = cis,cis-1,3,5-tris[(E,E)-3-(2-furyl)acrylideneamino]cyclohexane: structural models of carbonic anhydrase and liver alcohol dehydrogenase†,10.1039/B302895J

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Synthesis and structure of [Zn(OMe)(L)]·[Zn(OH)(L)]·2(BPh4), L = cis,cis-1,3,5-tris[(E,E)-3-(2-furyl)acrylideneamino]cyclohexane: structural models of carbonic anhydrase and liver alcohol dehydrogenase†

Leroy Cronin,Paul H. Walton

Chemical Communications Pub Date : 05/29/2003 00:00:00 , DOI:10.1039/B302895J

Abstract

Direct reaction of [Zn(OH)(L)]⁺, L = cis,cis-1,3,5-tris[(E,E)-3-(2-furyl)acrylideneamino]cyclohexane, with methanol gives a mixture of the starting material and [Zn(OMe)(L)]⁺; structural analysis of the complexes shows that they are models of reactive intermediates in the catalytic cycles of the zinc enzymes carbonic anhydrase and liver alcohol dehydrogenase.