Synthesis of 1,5-triazole bridged vancomycin CDE-ring bicyclic mimics using RuAAC macrocyclization†
Jinqiang Zhang,Johan Kemmink,Dirk T. S. Rijkers
Chemical Communications Pub Date : 03/28/2013 00:00:00 , DOI:10.1039/C3CC40628H
Abstract
Herein we report the Ru(II)-catalyzed double-macrocyclization of a hexapeptide to obtain a mimic of the bicyclic CDE-ring of vancomycin, followed by measurement of its binding affinity for small peptideligands using ITC.
