Synthesis of disulfides tethered pyrroles from β-ketothioamides via a bicyclization/ring-opening/oxidative coupling reaction†,10.1039/C7OB00655A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Synthesis of disulfides tethered pyrroles from β-ketothioamides via a bicyclization/ring-opening/oxidative coupling reaction†

Cong-Xiang Li,Rui-Juan Liu,Kun Yin,Li-Rong Wen,Ming Li

Organic & Biomolecular Chemistry Pub Date : 06/16/2017 00:00:00 , DOI:10.1039/C7OB00655A

Abstract

A DABCO-promoted three-component reaction of β-ketothioamides (KTAs), arylglyoxals and 2-cyanoacetates to construct disulfides tethered pyrroles by using air as an oxidant has been disclosed. Importantly, this protocol involves a tandem sequence that includes Knoevenagel condensation, Michael addition, N-cyclization, O-cyclization, ring-opening and oxidative coupling.