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Synthesis of ranitidine (Zantac) from cellulose-derived 5-(chloromethyl)furfural†
Mark Mascal,Saikat Dutta
Green Chemistry Pub Date : 09/19/2011 00:00:00 , DOI:10.1039/C1GC15537G
Abstract

The biomass-derived platform chemical 5-(chloromethyl)furfural is converted into the blockbuster antiulcer drug ranitidine (Zantac) in four steps with an overall 68% isolated yield.

Graphical abstract: Synthesis of ranitidine (Zantac) from cellulose-derived 5-(chloromethyl)furfural
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