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Synthesis of squaraine dyes under mild conditions: applications for labelling and sensing of biomolecules†
Mazen Haj Sleiman,Sylvain Ladame
Chemical Communications Pub Date : 12/18/2013 00:00:00 , DOI:10.1039/C3CC47894G
Abstract

We report the synthesis of squaraine dyes under mild conditions by carbodiimide activation of squaric acid or semi-squaraine dyes. Despite low yields when the reaction was carried out in solution, these conditions were successfully applied to efficient peptide labelling on resin and nucleic acid sensing in solution.

Graphical abstract: Synthesis of squaraine dyes under mild conditions: applications for labelling and sensing of biomolecules
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