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Tandem carbon–carbon bond insertion and intramolecular aldol reaction of benzyne with aroylacetones: novel formation of 4,4′-disubstituted 1,1′-binaphthols†
Kentaro Okuma,Ryoichi Itoyama,Ayumi Sou,Noriyoshi Nagahora,Kosei Shioj
Chemical Communications Pub Date : 09/26/2012 00:00:00 , DOI:10.1039/C2CC36128K
Abstract

An efficient route to 4-aryl-2-naphthols from arynes and aroylacetones was developed by carbon–carbon bond insertion followed by an intramolecular aldol reaction and dehydration. Benzyne derived from 2-(trimethylsilyl)phenyl triflate reacted with benzoylacetones in refluxing acetonitrile to give 4-aryl-2-naphthols and 3-aryl-1-naphthols.

Graphical abstract: Tandem carbon–carbon bond insertion and intramolecular aldol reaction of benzyne with aroylacetones: novel formation of 4,4′-disubstituted 1,1′-binaphthols
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