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Targeted delivery of photoactive diazido PtIV complexes conjugated with fluorescent carbon dots†
Xiao-Dong Yang,Hui-Jing Xiang,Lu An,Shi-Ping Yang,Jin-Gang Liu
New Journal of Chemistry Pub Date : 11/06/2014 00:00:00 , DOI:10.1039/C4NJ01758G
Abstract

A novel PtIV–azide@carbon dots (CDs) nanoplatform for photo-controlled targeted platinum drug delivery was developed. The PtIV–N3–FA@CDs nanoplatform selectively targeted folate-receptor overexpressed cancer cells while being simultaneously traced based on its inherent fluorescence; and it showed no dark cytotoxicity even in the presence of reducing glutathione, whereas it was readily photo-activated by either UV or visible light, producing cytotoxicity at a level comparable with that of cisplatin.

Graphical abstract: Targeted delivery of photoactive diazido PtIV complexes conjugated with fluorescent carbon dots
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