The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions†,10.1039/C1CC10973A

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

The 2-thiouridine unit in the RNA strand is desulfured predominantly to 4-pyrimidinone nucleoside under in vitro oxidative stress conditions†

Elzbieta Sochacka,Karina Kraszewska,Marek Sochacki,Milena Sobczak,Magdalena Janicka,Barbara Nawrot

Chemical Communications Pub Date : 03/24/2011 00:00:00 , DOI:10.1039/C1CC10973A

Abstract

The 2-thiouridine (S2U) unit in the RNA strand is predominantly desulfured with H₂O₂ to 4-pyrimidinone nucleoside (H2U). The resulting H2U-RNA exhibits significantly lower binding affinity to its complementary strand and in certain conditions undergoes strand scission. These results may explain the tRNA loss of biological function in oxidative stress conditions.