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Transannular Claisen rearrangement reactions for the synthesis of vinylcyclobutanes: formal synthesis of (±)-grandisol†
Donald Craig,Kiyohiko Funai,Sophie J. Gore,Albert Kang,Alexander V. W. Mayweg
Organic & Biomolecular Chemistry Pub Date : 10/06/2011 00:00:00 , DOI:10.1039/C1OB06619F
Abstract

Unsaturated eight-membered lactones undergo decarboxylative and non-decarboxylative transannular Ireland–Claisen rearrangement reactions, to give substituted vinylcyclobutanes. A formal synthesis of (±)-grandisol is described.

Graphical abstract: Transannular Claisen rearrangement reactions for the synthesis of vinylcyclobutanes: formal synthesis of (±)-grandisol
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