Vinyl fluoride as an isoelectronic replacement for an enolate anion: Inhibition of type II dehydroquinases
Martyn Frederickson,John R. Coggins,Chris Abell
Chemical Communications Pub Date : 07/26/2002 00:00:00 , DOI:10.1039/B205105M
Abstract
A vinyl fluoride analogue of the intermediate in the reaction catalysed by type II dehydroquinase enzymes has been synthesized over seven steps from (−)-quinic acid and shown to be a potent enzyme inhibitor.
