5-Formyl-2-furylboronic acid as a versatile bifunctional reagent for the synthesis of π-extended heteroarylfuran systems†,10.1039/B302767H

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5-Formyl-2-furylboronic acid as a versatile bifunctional reagent for the synthesis of π-extended heteroarylfuran systems†

Paul R. Parry,Martin R. Bryce,Brian Tarbit

Organic & Biomolecular Chemistry Pub Date : 04/04/2003 00:00:00 , DOI:10.1039/B302767H

Abstract

5-Formyl-2-furylboronic acid reacts cleanly with a range of heteroaryl bromides under Suzuki–Miyaura cross-coupling conditions to produce 2-formyl-5-heteroarylfuran derivatives. Subsequent Wittig olefination reactions afford π-conjugated alkene–pyridyl–furan derivatives.