The effect of Au-ion irradiation on the morphology, microstructure and lead-bismuth eutectic (LBE) corrosion behavior of refractory TiNbZrMoV high-entropy alloy coating was investigated. After irradiation, the surfaces of coatings were smoothened, and crystalline phase was formed in the coatings. After LBE corrosion at 650 °C, the irradiated samples presented a triple layer (interface Fe-Cr spinel, coating and surface Fe-oxide layer) consistent with the pristine sample, and the coating still maintained the low-consumption characteristic. Irradiation accelerated LBE corrosion, which could be attributed to the formation of grain boundary and defects that provided more diffusion channels for atoms.