C7-naphthylethynylated 8-aza-7-deaza-2′-deoxyguanosine naG was synthesized and its photophysical properties were examined. The fluorescent nucleoside exhibited solvatofluorochromic properties (Δλflmax = 67 nm). An ODN probe containing naG forms a stable base pair only with C and discriminates structural changes such as mismatches and deletions by a distinct change in its emission wavelength.
