Most studies have focused on the degradation of endocrine-disrupting chemicals using persulfate activation processes. Therefore, the current study compares various sulfate radical activation processes in an aqueous solution of a mixture of diethyl phthalate, butylparaben and bisphenol A that are present in water and wastewater. The effects of initial persulfate dose and pH variation, the effect of concentration of target endocrine-disrupting chemicals and degradation efficiency under various processes were studied. Additionally, the toxicity and cost estimation of the systems were also examined.