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Alkynylation/dearomatizative cyclization to construct spiro[5.5]undecanes†
Jidong Shao,Liqi Li,Jie Zhang,Jingping Hu,Jijun Xue,Ying Li
RSC Advances Pub Date : 03/22/2016 00:00:00 , DOI:10.1039/C6RA02463G
Abstract

A new access to spiro[5.5]undecane frameworks was reported through the ZnMe2-promoted alkynylation of salicylaldehyde and HCO2H-mediated dearomatizative cyclization which can be used to construct an all-carbon quaternary spirocenter. This method can be applied to the rapid synthesis towards a series of useful motifs of natural products, such as the core of elatol and aphidicolin.

Graphical abstract: Alkynylation/dearomatizative cyclization to construct spiro[5.5]undecanes
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