All-solid-state batteries (ASSBs) using inorganic solid electrolytes (SEs) are in the spotlight for next-generation energy storage devices because of their potential for outstanding safety and high energy density. Recent progress in this field has been primarily based on advances in materials, such as the discovery of SEs with high ionic conductivities and the improvement of interfacial stability in electrodes. However, the use of inelastic SEs causes severe electrochemo-mechanical failures, such as cathode active material (CAM) disintegration, CAM/SE contact loss, and stress build-up during cycling, deteriorating the Li+ and e− transport pathways. Although these concerns have been addressed previously, they have not been contextualized systematically in terms of the mechanical interactions among the components and their impacts on electrochemical performance. Here, we categorize the electrochemo-mechanical effect in ASSBs and its ramifications in terms of stress sources, active materials, composite electrodes, and cell stacks.