Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic†,10.1039/C5CC00904A

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Antibacterial properties and atomic resolution X-ray complex crystal structure of a ruthenocene conjugated β-lactam antibiotic†

Eric M. Lewandowski,Joanna Skiba,Nicholas J. Torelli,Aleksandra Rajnisz,Jolanta Solecka,Konrad Kowalski,Yu Chen

Chemical Communications Pub Date : 03/02/2015 00:00:00 , DOI:10.1039/C5CC00904A

Abstract

We have determined a 1.18 Å resolution X-ray crystal structure of a novel ruthenocenyle-6-aminopenicillinic acid in complex with CTX-M β-lactamase, showing unprecedented details of interactions between ruthenocene and protein. As the first product complex with an intact catalytic serine, the structure also offers insights into β-lactamase catalysis and inhibitor design.