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Application of Horner–Wadsworth–Emmons olefination for the synthesis of granulatamide A, its E isomer and other amides of tryptamine†
Deepali Pakhare,Radhika Kusurkar
New Journal of Chemistry Pub Date : 04/13/2016 00:00:00 , DOI:10.1039/C5NJ03533C
Abstract

Horner–Wadsworth–Emmons (HWE) Z-selective olefination was used for the first synthesis of a naturally occurring cytotoxic tryptamine derivative, granulatamide A. The E-isomer of granulatamide A was synthesized by E-selective HWE olefination. Furthermore, two other tryptamine derived amides were prepared by using the same strategy.

Graphical abstract: Application of Horner–Wadsworth–Emmons olefination for the synthesis of granulatamide A, its E isomer and other amides of tryptamine
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