Formal synthesis of isoquinocyclinone using ortho-alkoxycarbonylmethylation of anthranol via diazoquinone
MitsuruKitamura,NoriyukiFukuzumi,MasayukiShinagawa,KeiichiroAraki,YutaroShimizu,ShuheiTakahashi,TakumiIwata,HirokazuShimooka,TatsuoOkauchi
Abstract
In this study, a formal synthesis of isoquinocyclinone is reported. Synthesis of key intermediate lactone 6, an intermediate in Koert's s total synthesis of isoquinocyclinone, was succeeded. The lactone 6 was synthesized by using our developed diazo-transfer reaction of anthranol with 2-azido-1,3-dimethylimidazolinium chloride (ADMC) and alkoxycarbonylmethylation of diazoquinone as key reactions.
