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An approach to 6-trifluoromethyl-phenanthridines through visible-light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides†
Weijun Fu,Mei Zhu,Fengjuan Xu,Yuqin Fu,Chen Xu,Dapeng Zou
RSC Advances Pub Date : 03/28/2014 00:00:00 , DOI:10.1039/C4RA02384F
Abstract

A mild and efficient visible light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides is developed for the synthesis of 6-(trifluoromethyl)phenanthridine derivatives. The reaction involves the generation of radical intermediates from C(sp2)–Cl bonds and a homolytic radical aromatic substitution (HAS) process.

Graphical abstract: An approach to 6-trifluoromethyl-phenanthridines through visible-light-mediated intramolecular radical cyclization of trifluoroacetimidoyl chlorides
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