Applications of the amino-Cope rearrangement: synthesis of tetrahydropyran, δ-lactone and piperidine targets
Steven M. Allin,Munira Essat,Catarina Horro Pita,Robert D. Baird,Vickie McKee,Mark Elsegood,Mark Edgar,David M. Andrews,Pritom Shah,Ian Aspinall
Organic & Biomolecular Chemistry Pub Date : 01/26/2005 00:00:00 , DOI:
10.1039/B416179CAbstract
We report a novel approach to some chiral tetrahydropyran and δ-lactone targets that utilizes the asymmetric amino-Cope rearrangement as a key synthetic step. Products of amino-Cope rearrangement chemistry have also been applied to access piperidine targets, further demonstrating the potential of the methodology.
