Asymmetric synthesis of 1-substituted 2-azaspiro[3.3]heptanes: important motifs for modern drug discovery†,10.1039/C9CC00863B

批量搜索

批量搜索

热搜：

Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Asymmetric synthesis of 1-substituted 2-azaspiro[3.3]heptanes: important motifs for modern drug discovery†

Leleti Rajender Reddy,Yogesh Waman,Priya Kallure,Kumara Swamy Nalivela,Zubeda Begum,Thumbar Divya,Sharadsrikar Kotturi

Chemical Communications Pub Date : 03/07/2019 00:00:00 , DOI:10.1039/C9CC00863B

Abstract

Highly diastereoselective addition of ethyl cyclobutanecarboxylate anions to Davis–Ellman's imines is reported. This methodology afforded the preparation of enantiomerically and diastereomerically pure 1-substituted 2-azaspiro[3.3]heptanes. This three-step procedure proceeded efficiently (yield up to 90%) and diastereoselectively (dr values up to 98 : 2). This methodology is applicable to the synthesis of 1-substituted 2-azaspiro[3.4]octane and 1-substituted 2-azaspiro[3.5]nonane.