A perspective is given on the status and outlook of enabling technologies for process intensification in pharmaceutical research and manufacturing. We focus on three areas: photochemical, ultrasound, and microwave technologies that are, to date, underutilized in the pharmaceutical industry. Herein, we present a review of recent scientific and technological advances in each area with the objective to provide insight and highlight potential applications in the pharmaceutical industry. A perspective is also provided on barriers that must still be overcome to achieve the potential real-world application of these technologies.