A base promoted multigram synthesis of aminoisoxazoles: valuable building blocks for drug discovery and peptidomimetics†,10.1039/C6RA02365G

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

A base promoted multigram synthesis of aminoisoxazoles: valuable building blocks for drug discovery and peptidomimetics†

Bohdan A. Chalyk,Inna Y. Kandaurova,Kateryna V. Hrebeniuk,Olga V. Manoilenko,Irene B. Kulik,Rustam T. Iminov,Vladimir Kubyshkin,Anton V. Tverdokhlebov,Osman K. Ablialimov

RSC Advances Pub Date : 03/01/2016 00:00:00 , DOI:10.1039/C6RA02365G

Abstract

A practical multigram metal free synthesis of isoxazole-containing building blocks from commercially available amino acids was elaborated. The key reaction was a regioselective [3 + 2]-cycloaddition of in situ generated nitrile oxides with alkynes/enamines. The obtained building blocks were used in the preparation of bioactive compounds and peptidomimetics.