Five new flavonol acylglycosides, linderakosides A–E (1–5), together with 30 known compounds were isolated from the aerial part of Lindera akoensis Hayata. The structures were established using extensive spectroscopic analysis and comparison of NMR data with those of known compounds. The flavonol acylglycosides 1, 2, and 5 showed in vitro anti-inflammatory activity, which decreased LPS-stimulated nitrite production in RAW 264.7 cells. The structure activity relationships (SAR) of the flavonol acylglycoside compounds were also established to research for potential lead compounds as anti-inflammatory drugs.