Nanotechnology is an emerging field of science, engineering, and technology concerning the materials in nanoscale dimensions. Several materials are used in dentistry, which can be modified by applying nanotechnology. Nanotechnology has various applications in dentistry to achieve reliable treatment outcomes. The most common nanometals used in dental materials are gold, silver, copper oxide, magnesium oxide, iron oxide, cerium oxide, aluminum oxide, titanium dioxide, and zinc oxide (ZnO). ZnO nanoparticles (NPs), with their unparalleled properties such as high selectivity, enhanced cytotoxicity, biocompatibility, and easy synthesis as important materials were utilized in the field of dentistry. With this background, the present review aimed to discuss the current progress and gain an insight into applications of ZnO NPs in nanodentistry, including restorative, endodontic, implantology, periodontal, prosthodontics, and orthodontics fields.