Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase†,10.1039/C3CC40758F

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Antimicrobial N-(2-chlorobenzyl)-substituted hydroxamate is an inhibitor of 1-deoxy-d-xylulose 5-phosphate synthase†

Daisuke Hayashi,Nobuo Kato,Tomohisa Kuzuyama,Yasuo Sato,Junko Ohkanda

Chemical Communications Pub Date : 02/28/2013 00:00:00 , DOI:10.1039/C3CC40758F

Abstract

N-(2-Chlorobenzyl)-substituted hydroxamate, readily produced by hydrolysis of ketoclomazone, was identified as an inhibitor of 1-deoxy-D-xylulose 5-phosphate synthase (DXS), with an IC₅₀ value of 1.0 μM. The compound inhibited the growth of Haemophilus influenzae. A convenient spectroscopic method for assaying DXS using NADPH–lactate dehydrogenase (LDH) is also reported.