Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide†
Matthieu Lavayssiere,Frédéric Lamaty
Chemical Communications Pub Date : 02/22/2023 00:00:00 , DOI:10.1039/D2CC06934B
Abstract
The solventless synthesis of an amide was performed in a twin-screw extruder in the presence of a coupling agent, providing a high yielding and productive method. The reaction conditions were optimized to prepare APIs, teriflunomide and moclobemide.
