Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders†,10.1039/D2CC03135C

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Lactoyl-CoA 全氟丁基戊烷白叶藤碱全氟己基辛烷新白叶藤碱壳寡糖特色专题-生物多肽

Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders†

Simona Marzano,Francesco D'Amico,Silvia Di Fonzo,Eleonora Vertecchi,Erica Salvati,Anna Di Porzio,Bruno Catalanotti,Antonio Randazzo,Bruno Pagano,Jussara Amato

Chemical Communications Pub Date : 09/27/2022 00:00:00 , DOI:10.1039/D2CC03135C

Abstract

The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such RNA structures. Further in silico and in vitro assays identified three drugs as emerging SARS-CoV-2 RNA G-quadruplex binders.