Construction of nine-membered N,N,O-heterocycles via Pd-catalyzed [6+3] dipolar cycloaddition†,10.1039/D2CC03666E

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Construction of nine-membered N,N,O-heterocycles via Pd-catalyzed [6+3] dipolar cycloaddition†

Hongling Xie,Zhenkun Yang,Luning Tang,Zhengyu Han,Hai Huang

Chemical Communications Pub Date : 08/22/2022 00:00:00 , DOI:10.1039/D2CC03666E

Abstract

A new approach for the synthesis of 9-membered N,N,O-heterocycles by Pd-catalyzed [6+3] dipolar cycloaddition of N-iminoisoquinolinium ylides and 2-vinyl oxetanes has been developed. The scope of this cycloaddition was demonstrated with 28 examples. This is another important synthetic strategy for medium-sized rings by employing N-iminoisoquinolinium ylides as ternary synthons.